Synchronization clusters located on epileptic onset zones in neocortical epilepsy

Abstract Background Brain function is thought to rely on complex interactions of dynamic neural systems, which depend the integrity structural and functional networks. Focal epilepsy considered result from excessive focal synchronization in network. Synchronization analysis multichannel electrocorticography (ECoG) contributes understanding orientation epilepsy. The aim this study was explore ECoG recordings patients with neocortical characterize activity inside outside onset zone. Methods Four epilepsy, who became seizure-free for more than 1 year after surgery guided by monitoring, were included study. data recorded during pre-surgical evaluation analyzed. Synchronizations phase amplitude different frequency bands between channels analyzed using MATLAB. We generated 100 surrogate original Amplitude Adjusted Fourier Transform calculate enhanced synchronization. relationship characteristics seizure zone Results found clusters 14–30 Hz 30–80 around areas both interictal beginning ictal periods all four patients. Conclusions enhanced-synchronization play a central role may activate contribute spreading epileptiform activity.